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 第124回日本解剖学会で発表いたしました。（新潟, 3/27-3/29) ポスター ヒト胚子期における気管支分岐形成の3次元的解析; 藤井瀬菜、村中太河、松林潤、米山明男、武田徹、兵藤一行、山田重人、高桑徹也 胎児期初期における骨盤形成の解析; 金橋 徹、奥村 美咲、今井 宏彦、山田 重人、山本 憲、富樫 かおり、高桑 徹也 口演 ヒト胎児の顔面骨格形成とそれに必要な因子について; 勝部 元紀、山田 重人、山口 豊、高桑 徹也、山本 憲、斉藤 篤、清水 昭伸、今井 宏彦、鈴木 茂彦 シンポジウム 幾何学的形態測定学法を用いたヒト胎児脳の成長過程の解析; 山口豊、勝部元紀、上部千賀子、巻島美幸、山本憲、今井宏彦、高桑徹也、富樫かおり、山田重人  学部卒業式が行われました。おめでとうございます。大学院でも勉学にはげんでください。 第18回日本再生医療学会総会で発表しました (2019.3.21@神戸市) 再生医療において、重要な課題である細胞や組織の生死評価を行いました。3次元構造をとる組織は基質を有し、遊離した細胞よりも測定方法が困難であるとされていますが、本研究では３Dバイオプリンターを用いて３次元構造の組織体を作製し、組織構成体の摘出手法および生死評価手法について検討しました。（今後は、このような３次元的組織構成体の生死判定は移植前の組織の安全性を測るのみでなく移植後のリハビリテーションの有効性の検討を行う際の組織状態のベースラインの確認にも有用であると考えられます。） 石川葵、田中麻衣、杉山寛恵、池口良輔、高井治美、鳥井蓉子、國富芳博、秋枝静香、青山朋樹、高桑徹也 「神経様３次元組織体の生死判定技術の検討」 長田さん、八田くんの卒業論文がJournal of Anatomy に掲載されました。 ヒトの消化管は一時的に臍帯内に脱出しCRL40 mmころ、突然還納します（生理的ヘルニア）。生理的ヘルニアの脱出については論文がある程度ありますが、還納過程については研究がほとんどなく、不明な点が多くありました。今回の解析では、還納途中の３体を含む２５体について形態計測的な検討をし以下の知見をえました。 
35. Nagata A, Hatta S, Ji X, Ishikawa A, Sakamoto R, Yamada S, Imai H, Matsuda T, Takakuwa T. Return of the intestinal loop to the abdominal coelom after physiological umbilical herniation in the early fetal period. J Anat, 2019, 234, 456-464.doi: 10.1111/joa.12940. AbstractThe intestine elongates during the early fetal period, herniates into the extraembryonic coelom, and subsequently returns to the abdominal coelom. The manner of herniation is well-known; however, the process by which the intestinal loop returns to the abdomen is not clear. Thus, the present study was designed to document and measure intestinal movements in the early fetal period in three dimensions to elucidate the intestinal loop return process. Magnetic resonance images from human fetuses whose intestinal loops herniated (herniated phase; n = 5) while returning to the abdominal coelom [transition phase; n = 3, crown–rump length (CRL)] 37, 41, and 43 mm] and those whose intestinal loops returned to the abdominal coelom normally (return phase; n = 12) were selected from the Kyoto Collection. Intestinal return began from proximal to distal in samples with CRL of 37 mm. Only the ileum ends were observed in the extraembryonic coelom in samples with CRLs of 41 and 43 mm, whereas the ceca were already located in the abdominal coeloms. The entire intestinal tract had returned to the abdominal coelom in samples with CRL > 43 mm. The intestinal length increased almost linearly with fetal growth irrespective of the phase (R2 = 0.90). The ratio of the intestinal length in the extraembryonic coelom to the entire intestinal length was maximal in samples with CRLs of 32 mm (77%). This ratio rapidly decreased in three of the samples that were in the transition phase. The abdominal volumes increased exponentially (to the third power) during development. The intestinal volumes accounted for 33–41% of the abdominal volumes among samples in the herniated phase. The proportion of the intestine in the abdominal cavity increased, whereas that in the liver decreased, both without any break or plateau. The amount of space available for the intestine by the end of the transition phase was approximately 200 mm3. The amount of space available for the intestine in the abdominal coelom appeared to be sufficient at the beginning of the return phase in samples with CRLs of approximately 43 mm compared with the maximum intestinal volume available for the extraembryonic coelom in the herniated phase, which was 25.8 mm3 in samples with CRLs of 32 mm. A rapid increase in the space available for the intestine in the abdominal coelom that exceeded the intestinal volume in the extraembryonic coelom generated an inward force, leading to a ‘sucked back’ mechanism acting as the driving force. The height of the hernia tip increased to 8.9 mm at a maximum fetal CRL of 37 mm. The height of the umbilical ring increased in a stepwise manner between the transition and return phases and its height in the return phase was comparable to or higher than that of the hernia tip during the herniation phase. We surmised that the space was generated in the aforementioned manner to accommodate the herniated portion of the intestine, much like the intestine wrapping into the abdominal coelom as the height of the umbilical ring increased.  卒業おめでとうございます。博士3年季 翔 （青山研） 修士2年 鈴木裕子 西谷早織 学部４回生坂本 梨乃 寺島 芽衣（進学） 野原 葵（進学） 山崎 優（進学）  多元計算解剖学第5回国際シンポジウム(The 5th International Symposium on Multidisciplinary Computational Anatomy)で発表しました。(3/4-5, 九州大学)
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