ヒトのWillis輪の形成についての論文がCongenitAnomに掲載されました。
Willis輪は脳を養う血流が脳底部で輪状にあつまる部位で、成人ではvariationが多いことが知られています。
本論文では、20例の胚子期後期標本について検討し、以下の知見をえました。
- Willis輪がCS22ころ完成すること
- 胚子期後期でもvariationが多くみられること
- Willis輪が未完成の標本が、成長に伴い完成したかはあきらかでないこと
25. Takakuwa T, Koike T, Muranaka T, Yamada S, Uwabe C. 2016. Formation of the circle of Willis during human embryonic development. Congenit Anom (Kyoto) 2016; 56, 233–236, DOI: 10.1111/cga.12165
Abstract
The circle of Willis (CW) is a circulatory anastomosis that supplies blood to the brain and adjacent structures. We examined the timing of formation of CW in 20 Japanese human embryo samples by using 3-dimensional reconstruction of serial histological sections. The CW was closed in 1 (n = 6), 2 (n = 8), 2 (n = 3) and 2 (n = 3) samples at Carnegie stages 20, 21, 22, and 23, respectively. The CW was unclosed in 13 samples (unclosed at ACOM alone, 6 samples; ACOM and bilateral P1, 4; left PCOM and right P1, 1; right PCOM and right P1, 1; ACOM and left PCOM, 1). It was difficult to predict whether the circle would close during further development, as such variations frequently exist in adults.